Yahoo! reports that Spider-Man and Mary Jane are no longer married anymore. They didn't get a divorce it turns out, but agreed with Mephisto to erase their marriage in exchange for saving Aunt May's life.
Petey and Mary Jane have been married for twenty-one of our years. I don't know what that translates into super-hero years, but apparently Marvel Comics was feeling restless and wanted to shake things up.
At least they didn't kill Spider-Man off and then have him come back as four gay versions of himself *cough*Death of Superman*cough*.